Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 6/20 | 0.48 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3871323 | 0.95 | KIF11 (0.49) | KIF11KIF23KDM4EGAAMAPT | |
| SCHEMBL5899029 | 0.90 | KIF11 (0.47) | KIF11KIF23KDM4EGAAMAPT | |
| SCHEMBL4057634 | 0.89 | KIF11 (0.51) | KIF11KIF23KDM4EGAAMAPT | |
| SCHEMBL4060625 | 0.86 | KIF11 (0.41) | KIF11KIF23MAPTNPSR1GNRHR | |
| SCHEMBL3866928 | 0.85 | KIF11 (0.52) | KIF11KIF23 | |
| SCHEMBL3863849 | 0.84 | KIF11 (0.49) | KIF11KIF23KDM4EGAAMAPT | |
| SCHEMBL4039243 | 0.83 | KIF11 (0.53) | KIF11KIF23KDM4EGAAMAPT | |
| SCHEMBL4036178 | 0.82 | KIF11 (0.46) | KIF11KIF23BRD4 | |
| SCHEMBL4046310 | 0.81 | KIF11 (0.53) | KIF11KIF23KDM4EGAAMAPT | |
| SCHEMBL3867071 | 0.81 | KIF11 (0.59) | KIF11KIF23KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601673-B1 | FUSED HETEROCYCLES AND USES THEREOF | ASTRAZENECA AB (SE) | 2009-06-10 | — | — | EP | disclosed |