Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043896 | 0.97 | HTT (0.42) | TRPV1TDP1MEN1LMNAHTT | |
| SCHEMBL4042940 | 0.85 | TSHR (0.45) | TDP1MEN1LMNAHTTKMT2A | |
| SCHEMBL4039550 | 0.84 | LMNA (0.44) | MEN1LMNAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL4037453 | 0.84 | EPHX1 (0.43) | TDP1MEN1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL4042732 | 0.84 | NR1H4 (0.44) | MEN1HTTKMT2ASMN1; SMN2MDM2 | |
| SCHEMBL4040005 | 0.84 | KMT2A (0.43) | MEN1LMNAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL4039101 | 0.84 | NR1H4 (0.44) | MEN1HTTKMT2ASMN1; SMN2MDM2 | |
| SCHEMBL4041915 | 0.82 | SMN1; SMN2 (0.42) | TDP1MEN1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL4040671 | 0.82 | NPC1 (0.45) | TDP1MEN1LMNAHTTKMT2A | |
| SCHEMBL4041199 | 0.82 | SMN1; SMN2 (0.47) | MEN1LMNAHTTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038259-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008000643-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |