Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.61 |
| ▸ | DRD3 | P35462 | 9/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD5 | P21918 | 1/20 | 0.49 |
| ▸ | HRH2 | P25021 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041382 | 0.92 | DRD2 (0.71) | DRD2DRD3NPC1RAB9AMEN1 | |
| Octadecylamine SCHEMBL11510428 | 0.79 | HSD11B1 (0.56) | DRD2 | |
| SCHEMBL4385569 | 0.79 | DRD2 (0.71) | DRD2DRD3NPC1RAB9AMEN1 | |
| SCHEMBL11512132 | 0.78 | DRD2 (0.78) | DRD2DRD3NPC1RAB9AMEN1 | |
| SCHEMBL392717 | 0.78 | HSD11B1 (0.53) | DRD2NPC1RAB9AKMT2AL3MBTL1 | |
| SCHEMBL4705828 | 0.75 | DRD2 (0.66) | DRD2DRD3NPC1RAB9AMEN1 | |
| SCHEMBL4702745 | 0.73 | DRD2 (0.63) | DRD2DRD3NPC1RAB9AMEN1 | |
| SCHEMBL9224636 | 0.73 | DRD2 (0.77) | DRD2DRD3NPC1RAB9AMEN1 | |
| SCHEMBL4197148 | 0.71 | NPC1 (0.81) | DRD2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL4206819 | 0.69 | NPC1 (0.66) | DRD2DRD3NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140908-B1 | TRIAZOLE COMPOUNDS WITH DOPAMINE-D3-RECEPTOR AFFINITY | ABBOTT GMBH & CO KG (DE) | 2009-03-04 | — | — | EP | disclosed |
| US-6579892-B1 | Affective disorders; neurotic, stress and somatoform disorders and psychoses, e.g. schizophrenia 3-(3-(6-Methyl-1,2,3,4-tetrahydronaphth-2-ylamino)propylmercap to) -4-methyl-5-phenyl-1,2,4(4H)-triazole | ABBOTT LABORATORIES | 2003-06-17 | — | — | US | disclosed |