Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 16/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL4054052 | 1.00 | KCNH2 (0.47) | KCNH2 | |
| Bicarbonate SCHEMBL4042317 | 0.89 | KCNH2 (0.48) | KCNH2 | |
| SCHEMBL5263291 | 0.85 | KCNH2 (0.45) | KCNH2 | |
| SCHEMBL3573168 | 0.85 | KCNH2 (0.45) | KCNH2 | |
| SCHEMBL3576397 | 0.85 | KCNH2 (0.45) | KCNH2 | |
| Bicarbonate SCHEMBL5749485 | 0.80 | KCNH2 (0.48) | KCNH2 | |
| Bicarbonate SCHEMBL5740452 | 0.80 | KCNH2 (0.48) | KCNH2 | |
| Bicarbonate SCHEMBL4045725 | 0.79 | KCNH2 (0.41) | KCNH2 | |
| Bicarbonate SCHEMBL4043287 | 0.79 | KCNH2 (0.41) | KCNH2 | |
| Bicarbonate SCHEMBL4044942 | 0.79 | KCNH2 (0.41) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537123-B1 | AMINO-SUBSTITUTED CYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS | GLAXO GROUP LTD (GB) | 2009-04-29 | — | — | EP | claimed |