Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | BUB1 | O43683 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22763030 | 0.81 | USP2 (0.38) | PTPN2PTPN1PTPN6GPR119USP30 | |
| SCHEMBL4041214 | 0.80 | NEK2 (0.38) | HDAC1HDAC2NPC1RAB9A | |
| SCHEMBL30585823 | 0.77 | PTPN2 (0.46) | PTPN2PTPN1PTPN6ABL1RIN1 | |
| SCHEMBL21639881 | 0.77 | PTPN2 (0.46) | PTPN2PTPN1PTPN6ABL1RIN1 | |
| SCHEMBL31596935 | 0.77 | PTPN2 (0.52) | PTPN2PTPN1PTPN6ABL1RIN1 | |
| SCHEMBL4911832 | 0.77 | LMNA (0.51) | PTPN2PTPN1PTPN6ABL1RIN1 | |
| SCHEMBL21641259 | 0.74 | PTPN2 (0.43) | PTPN2PTPN1PTPN6ABL1RIN1 | |
| SCHEMBL5492751 | 0.74 | NTRK1 (0.44) | PTPN2PTPN1PTPN6ABL1RIN1 | |
| SCHEMBL21640304 | 0.73 | PTPN2 (0.50) | PTPN2PTPN1PTPN6ABL1RIN1 | |
| SCHEMBL21640789 | 0.73 | DEGS1 (0.54) | PTPN2PTPN1PTPN6ABL1RIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009029592-A1 | HETEROBICYCLIC-SUBSTITUTED QUINOLONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | KALYPSYS, INC. (US) | 2009-03-05 | — | — | WO | disclosed |
| WO-2009029592-A1 | HETEROBICYCLIC-SUBSTITUTED QUINOLONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | KALYPSYS, INC. (US) | 2009-03-05 | — | — | WO | disclosed |