Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 7/20 | 0.52 |
| ▸ | MAOB | P27338 | 7/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 5/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14263757 | 1.00 | MAOA (0.52) | MAOAMAOBHRH3CYP2D6HRH1 | |
| SCHEMBL14019406 | 0.82 | HRH3 (0.46) | MAOAMAOBHRH3CYP2D6HRH1 | |
| SCHEMBL12471689 | 0.80 | HRH3 (0.52) | MAOAMAOBHRH3CYP2D6HRH1 | |
| SCHEMBL8728467 | 0.80 | ITGB3 (0.60) | MAOAMAOBHRH3CYP2D6HRH1 | |
| SCHEMBL12471199 | 0.79 | HRH3 (0.51) | MAOAMAOBHRH3CYP2D6HRH1 | |
| SCHEMBL6701989 | 0.78 | KDM1A (0.53) | MAOAMAOBHRH3CYP2D6HRH1 | |
| SCHEMBL12472170 | 0.76 | HRH3 (0.57) | HRH3CYP2D6HRH1FAAH | |
| SCHEMBL17067890 | 0.76 | HRH3 (0.56) | MAOAMAOBHRH3CYP2D6HRH1 | |
| SCHEMBL13866864 | 0.75 | HRH3 (0.43) | MAOAMAOBHRH3CYP2D6HRH1 | |
| SCHEMBL4049731 | 0.75 | HRH3 (0.43) | MAOAMAOBHRH3CYP2D6HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503998-B1 | HETEROARYL SUBSTITUTED SPIROCYCLIC SUFAMIDES FOR INHIBITION OF GAMMA SECRETASE | MERCK SHARP & DOHME (GB) | 2009-07-01 | — | — | EP | disclosed |
| US-20080070895-A1 | Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase | COLLINS IAN J | 2008-03-20 | — | — | US | disclosed |
| US-7282513-B2 | Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase | MERCK SHARP & DOHME LIMITED (GB) | 2007-10-16 | — | — | US | disclosed |
| US-7183303-B2 | Gamma-secretase inhibitors | MERCK SHARP & DOHME LIMITED (GB) | 2007-02-27 | — | — | US | disclosed |
| US-7138400-B2 | Sulfamides as gamma-secretase inhibitors | MERCK SHARP & DOHME LIMITED (GB) | 2006-11-21 | — | — | US | disclosed |
| US-20060173054-A1 | Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2006-08-03 | — | — | US | disclosed |
| US-7041689-B2 | Heteroaryl substituted spriocyclic sulfamides for inhibition of gamma secretase | MERCK SHARP & DOHME LTD. (GB) | 2006-05-09 | — | — | US | disclosed |
| EP-1334085-B1 | SULFAMIDES AS GAMMA-SECRETASE INHIBITORS | MERCK SHARP & DOHME (GB) | 2005-08-24 | — | — | EP | disclosed |
| US-20050182109-A1 | Heteroaryl substituted spriocyclic sulfamides for inhibition of gamma secretase | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182109-A1 | Heteroaryl substituted spriocyclic sulfamides for inhibition of gamma secretase | BACE1, BACE2, PSEN1 | MAOA 1509/4885MAOB 2179/4885HRH3 699/4885 |
| US-20060173054-A1 | Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase | BACE1, BACE2, PSEN1 | MAOA 1695/4885MAOB 2136/4885HRH3 1706/4885 |
| US-20080070895-A1 | Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase | BACE1, BACE2, PSEN1 | MAOA 1695/4885MAOB 2136/4885HRH3 1706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.