Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 9/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035139 | 0.90 | GAA (0.43) | SIGMAR1KMT2AGAA | |
| SCHEMBL3994486 | 0.89 | MCHR1 (0.37) | MCHR1SIGMAR1ACHEKMT2AMEN1 | |
| SCHEMBL4206788 | 0.88 | KMT2A (0.35) | MCHR1SIGMAR1ACHEKMT2AMEN1 | |
| SCHEMBL4033395 | 0.87 | MCHR1 (0.36) | MCHR1SIGMAR1ACHEKMT2AMEN1 | |
| SCHEMBL1810683 | 0.87 | ACHE (0.36) | MCHR1SIGMAR1ACHEKMT2AMEN1 | |
| SCHEMBL3995879 | 0.86 | KMT2A (0.38) | MCHR1SIGMAR1ACHEKMT2AMEN1 | |
| SCHEMBL4035046 | 0.86 | GAA (0.35) | SIGMAR1KMT2AGAACYP3A4CYP2D6 | |
| SCHEMBL4037652 | 0.84 | CHRM3 (0.41) | KMT2AGAACCR3 | |
| Dimethylamine SCHEMBL3987722 | 0.83 | ACHE (0.35) | MCHR1SIGMAR1ACHEKMT2AGAA | |
| SCHEMBL1808149 | 0.82 | DRD4 (0.39) | MCHR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |
| EP-1730144-A1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5|DECAN-2-ONE COMPOUNDS | Grünenthal GmbH (DE) | 2006-12-13 | — | — | EP | claimed |
| WO-2005095398-A1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4.5]DECAN-2-ONE COMPOUNDS | Grünenthal GmbH (DE) | 2005-10-13 | — | — | WO | claimed |