Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PARG | Q86W56 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3872559 | 0.89 | KIF11 (0.54) | KIF11ALDH1A1SLC26A6CYP1A2CYP2C19 | |
| SCHEMBL4058305 | 0.88 | KIF11 (0.44) | KIF11ALDH1A1HTTSLC26A6KMT2A | |
| SCHEMBL4043250 | 0.87 | KIF11 (0.42) | KIF11ALDH1A1HTTSLC26A6CYP1A2 | |
| SCHEMBL4043063 | 0.81 | SMN1; SMN2 (0.44) | KIF11ALDH1A1HTTSLC26A6CYP1A2 | |
| SCHEMBL4037033 | 0.79 | KIF11 (0.49) | KIF11ALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL3888693 | 0.76 | KIF11 (0.51) | KIF11ALDH1A1HTTSLC26A6CYP1A2 | |
| SCHEMBL5898996 | 0.76 | KIF11 (0.58) | KIF11ALDH1A1SLC26A6CYP1A2CYP2C19 | |
| SCHEMBL4060901 | 0.76 | KIF11 (0.42) | KIF11ALDH1A1HTTSLC26A6KMT2A | |
| SCHEMBL3865933 | 0.75 | KIF11 (0.69) | KIF11CYP3A4CYP2C19 | |
| SCHEMBL3871270 | 0.75 | KIF11 (0.69) | KIF11CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601673-B1 | FUSED HETEROCYCLES AND USES THEREOF | ASTRAZENECA AB (SE) | 2009-06-10 | — | — | EP | disclosed |