SCHEMBL4043063

SCHEMBL4043063

Cc1noc2nc(CC(C)C)n(Cc3ccc(F)cc3)c(=O)c12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.44
ALDH1A1 P00352 4/20 0.40
HTT P42858 1/20 0.40
SLC26A6 Q9BXS9 1/20 0.39
CYP1A2 P05177 5/20 0.39
CYP3A4 P08684 5/20 0.39
CYP2C19 P33261 5/20 0.39
CYP2C9 P11712 4/20 0.39
USP2 O75604 3/20 0.39
TP53 P04637 1/20 0.39
KIF11 P52732 1/20 0.38
KMT2A Q03164 4/20 0.38
MEN1 O00255 3/20 0.38
HSD17B10 Q99714 3/20 0.38
TSHR P16473 2/20 0.38
MAPK1 P28482 2/20 0.38
HPGD P15428 1/20 0.38
HIF1A Q16665 1/20 0.38
ALOX5AP P20292 1/20 0.38
LMNA P02545 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3901729 0.89 SMN1; SMN2 (0.48) SMN1; SMN2ALDH1A1SLC26A6CYP1A2CYP2C19
SCHEMBL4059248 0.87 SLC26A6 (0.43) SMN1; SMN2ALDH1A1HTTSLC26A6KIF11
SCHEMBL4043250 0.81 KIF11 (0.42) SMN1; SMN2ALDH1A1HTTSLC26A6CYP1A2
SCHEMBL4046482 0.81 KIF11 (0.44) SMN1; SMN2ALDH1A1HTTSLC26A6CYP1A2
SCHEMBL6208219 0.78 SMN1; SMN2 (0.45) SMN1; SMN2ALDH1A1SLC26A6CYP1A2CYP2C19
SCHEMBL6208130 0.78 KIF11 (0.48) SMN1; SMN2ALDH1A1SLC26A6CYP1A2CYP2C19
SCHEMBL5237790 0.78 SLC26A6 (0.41) SMN1; SMN2ALDH1A1HTTSLC26A6KIF11
SCHEMBL5234446 0.78 BRD4 (0.42) SMN1; SMN2ALDH1A1HTTSLC26A6KIF11
SCHEMBL4037664 0.78 TP53 (0.41) ALDH1A1CYP1A2CYP3A4CYP2C19CYP2C9
SCHEMBL3957538 0.76 KIF11 (0.55) CYP3A4CYP2C19KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1601673-B1 FUSED HETEROCYCLES AND USES THEREOF ASTRAZENECA AB (SE) 2009-06-10 EP disclosed