Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 8/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12592908 | 0.88 | PIK3CG (0.41) | PIK3CGCYP2C9PRKDCADORA3ADORA2A | |
| SCHEMBL1760997 | 0.85 | PIK3CG (0.36) | PIK3CGCYP2C9PRKDCADORA3ADORA2A | |
| SCHEMBL1760927 | 0.77 | SCD (0.40) | PIK3CGCYP2C9PRKDCABL1 | |
| SCHEMBL1760909 | 0.76 | RAF1 (0.40) | PIK3CGCYP2C9PRKDCGSK3AGSK3B | |
| SCHEMBL1761038 | 0.75 | CCNE1 (0.48) | ADORA3ADORA2AADORA1SMN1; SMN2NPC1 | |
| SCHEMBL4054563 | 0.74 | ADORA2A (0.40) | ADORA3ADORA2AADORA1HSD17B10TSHR | |
| SCHEMBL13176908 | 0.74 | ADORA2A (0.48) | PIK3CGADORA3ADORA2AADORA1SMN1; SMN2 | |
| SCHEMBL1760974 | 0.73 | ADORA2A (0.45) | ADORA3ADORA2AADORA1HSD17B10SMN1; SMN2 | |
| SCHEMBL13176525 | 0.73 | MAPT (0.46) | ADORA3ADORA2AADORA1HSD17B10SMN1; SMN2 | |
| SCHEMBL4049475 | 0.72 | ADORA2A (0.42) | PIK3CGADORA3ADORA2AADORA1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-A1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007134958-A1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-11-29 | — | — | WO | disclosed |