Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 12/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13176908 | 0.91 | ADORA2A (0.48) | ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL1761075 | 0.88 | ADORA2A (0.40) | ADORA2AADORA1ADORA3ADORA2BNPY5R | |
| SCHEMBL12592691 | 0.88 | ADORA2A (0.41) | ADORA2AADORA1ADORA3ADORA2BMAPT | |
| Hydrochloric Acid SCHEMBL1760985 | 0.87 | ADORA2A (0.40) | ADORA2AADORA1ADORA3ADORA2BMAPT | |
| SCHEMBL1760961 | 0.86 | MAPT (0.41) | ADORA2AADORA1ADORA3ADORA2BMAPT | |
| SCHEMBL1760991 | 0.86 | ADORA2A (0.46) | ADORA2AADORA1ADORA3ADORA2BMAPT | |
| SCHEMBL4049475 | 0.85 | ADORA2A (0.42) | ADORA2AADORA1ADORA3ADORA2BMAPT | |
| SCHEMBL1760859 | 0.85 | FAAH (0.50) | MAPTALDH1A1HSD17B10FAAH | |
| SCHEMBL1761051 | 0.84 | MAPK1 (0.48) | ADORA2AMAPTALDH1A1TSHRFAAH | |
| Trifluoroacetic Acid SCHEMBL1760936 | 0.84 | PKM (0.40) | ADORA2AADORA1ADORA3ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-A1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007134958-A1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-11-29 | — | — | WO | disclosed |