Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 10/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050561 | 0.94 | PIK3CD (0.41) | ADORA2AADORA1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL4049256 | 0.94 | PIK3CD (0.41) | ADORA2AADORA1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL1760880 | 0.88 | NAMPT (0.42) | ADORA2AADORA1PIK3CD | |
| SCHEMBL1760991 | 0.87 | ADORA2A (0.46) | ADORA2AADORA1PIK3CDPIK3CAALDH1A1 | |
| SCHEMBL4054563 | 0.85 | ADORA2A (0.40) | ADORA2AADORA1ALDH1A1MAPTTSHR | |
| SCHEMBL13176908 | 0.85 | ADORA2A (0.48) | ADORA2AADORA1PIK3CDPIK3CAADORA3 | |
| SCHEMBL1760963 | 0.83 | ADORA2A (0.42) | ADORA2AADORA1PIK3CDPIK3CAALDH1A1 | |
| SCHEMBL1760877 | 0.83 | ADORA2A (0.42) | ADORA2AADORA1PIK3CDPIK3CAALDH1A1 | |
| SCHEMBL12592880 | 0.83 | ADORA2A (0.42) | ADORA2AADORA1PIK3CDPIK3CAALDH1A1 | |
| SCHEMBL12592888 | 0.82 | HDAC3 (0.46) | ADORA2AADORA1PIK3CDPIK3CAADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-A1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007134958-A1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-11-29 | — | — | WO | disclosed |