Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 20/20 | 0.68 |
| ▸ | OGFRL1 | Q5TC84 | 13/20 | 0.68 |
| ▸ | OPRL1 | P41146 | 11/20 | 0.68 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.68 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055133 | 0.89 | OPRM1 (0.73) | OPRM1OGFRL1OPRL1OPRK1OPRD1 | |
| Trifluoromethanesulfonic Acid SCHEMBL4047154 | 0.89 | OPRM1 (0.56) | OPRM1OGFRL1OPRL1OPRK1OPRD1 | |
| Citric Acid SCHEMBL4047655 | 0.87 | OPRM1 (0.53) | OPRM1OGFRL1OPRL1OPRK1OPRD1 | |
| Trifluoromethanesulfonic Acid SCHEMBL4053432 | 0.82 | OPRM1 (0.59) | OPRM1OGFRL1OPRL1OPRK1OPRD1 | |
| Trifluoromethanesulfonic Acid SCHEMBL4059045 | 0.81 | OPRM1 (0.62) | OPRM1OGFRL1OPRL1OPRK1OPRD1 | |
| Citric Acid SCHEMBL4054564 | 0.81 | OPRM1 (0.47) | OPRM1OGFRL1OPRL1OPRK1OPRD1 | |
| SCHEMBL12918431 | 0.81 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRK1OPRD1 | |
| SCHEMBL380074 | 0.81 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL1304169 | 0.80 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRK1OPRD1 | |
| SCHEMBL4049796 | 0.76 | OPRM1 (0.56) | OPRM1OGFRL1OPRL1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697379-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2009-03-25 | — | — | EP | claimed |
| US-7288560-B2 | Spirocyclic cyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2007-10-30 | — | — | US | claimed |
| US-20050187281-A1 | Spirocyclic cyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2005-08-25 | — | — | US | claimed |
| EP-1697379-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2009-03-25 | — | — | EP | disclosed |
| US-7288560-B2 | Spirocyclic cyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2007-10-30 | — | — | US | disclosed |
| US-20050187281-A1 | Spirocyclic cyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050187281-A1 | Spirocyclic cyclohexane derivatives | PKD2, PKD1, VKORC1 | OPRM1 1427/4885OGFRL1 2552/4885OPRL1 781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.