Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038703 | 0.87 | PARP1 (0.36) | PARP1LMNAMAPTPKMF2 | |
| SCHEMBL6208713 | 0.75 | PARP1 (0.36) | PARP1LMNAF2F10PRSS1 | |
| SCHEMBL4044079 | 0.75 | CTSL (0.33) | PARP1 | |
| SCHEMBL4046219 | 0.75 | PARP1 (0.35) | PARP1LMNAF2F10PRSS1 | |
| SCHEMBL4040449 | 0.73 | DPP4 (0.43) | PARP1LMNAMAPTPKMF2 | |
| SCHEMBL4042202 | 0.73 | PARP1 (0.30) | PARP1 | |
| SCHEMBL4042160 | 0.73 | PARP1 (0.34) | PARP1LMNAPKMF2F10 | |
| SCHEMBL4044726 | 0.73 | PARP1 (0.34) | PARP1LMNAF2F10PRSS1 | |
| SCHEMBL6209170 | 0.73 | PARP1 (0.35) | PARP1LMNAPKMF2F10 | |
| SCHEMBL4045821 | 0.73 | PARP1 (0.35) | PARP1F2F10PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |