Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047171 | 0.80 | PTPN2 (0.58) | LMNAALDH1A1CYP17A1NPSR1MAPT | |
| Hydrochloric Acid SCHEMBL4056640 | 0.77 | NPSR1 (0.46) | LMNAALDH1A1CYP17A1NPSR1POLB | |
| SCHEMBL14837761 | 0.73 | CYP17A1 (0.49) | CYP17A1TSHRCYP26A1KDM4EMEN1 | |
| SCHEMBL13720325 | 0.69 | KDM4E (0.54) | ALDH1A1CYP17A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL5566007 | 0.68 | CYP17A1 (0.43) | CYP17A1CYP26A1KDM4E | |
| SCHEMBL2265355 | 0.64 | ALDH1A1 (0.36) | LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL26673858 | 0.64 | MAPT (0.47) | LMNANPSR1POLBMAPT | |
| SCHEMBL4990110 | 0.64 | STS (0.62) | ALDH1A1NPSR1POLBHPGDMAPT | |
| SCHEMBL16456936 | 0.64 | LMNA (0.33) | LMNA | |
| SCHEMBL14837689 | 0.64 | CYP17A1 (0.48) | CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579352-B2 | Retinoic acid mimetic anilides | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-08-25 | — | — | US | disclosed |