Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 8/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL40042 | 0.92 | SERPINE1 (0.51) | SERPINE1MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2719825 | 0.85 | MAP4K4 (0.43) | MAPTCYP1A2CYP3A4CYP2C19MET | |
| SCHEMBL46439 | 0.85 | ABL1 (0.47) | SERPINE1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL46749 | 0.84 | SERPINE1 (0.41) | SERPINE1MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL40398 | 0.83 | MAPT (0.49) | SERPINE1MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL46764 | 0.81 | MET (0.46) | SERPINE1MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL40152 | 0.81 | SERPINE1 (0.50) | SERPINE1MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL46429 | 0.79 | CYP1A2 (0.53) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL40054 | 0.78 | MAPT (0.43) | SERPINE1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL45418 | 0.77 | MAPT (0.43) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| EP-2590656-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |