Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PKLR | P30613 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MGAM | O43451 | 2/20 | 0.41 |
| ▸ | SI | P14410 | 2/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4044510 | 0.76 | MAPT (0.46) | CTSVCTSLPOLBPARP1MEN1 | |
| SCHEMBL3328845 | 0.73 | L3MBTL1 (0.54) | POLBSLC6A4MEN1KMT2A | |
| SCHEMBL947462 | 0.69 | MGAM (0.55) | POLBGAAMGAMSIMGAM2 | |
| SCHEMBL982452 | 0.69 | ELANE (0.65) | CTSVCTSLPOLBELANESLC6A4 | |
| SCHEMBL28110480 | 0.69 | CTSV (0.60) | CTSVCTSLPOLBPARP1MEN1 | |
| SCHEMBL9085790 | 0.68 | CDK4 (0.67) | CTSVCTSLELANESLC6A4PARP1 | |
| SCHEMBL13302290 | 0.67 | ELANE (0.54) | CTSVCTSLPOLBELANESLC6A4 | |
| SCHEMBL30272742 | 0.67 | CTSV (0.79) | CTSVCTSLPOLBPARP1MEN1 | |
| SCHEMBL30272741 | 0.67 | CTSV (0.79) | CTSVCTSLPOLBPARP1MEN1 | |
| SCHEMBL30272743 | 0.67 | CTSV (0.79) | CTSVCTSLPOLBPARP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081892-A1 | COMPOUNDS AND METHODS FOR TREATING PROTEIN FOLDING DISORDERS | Queen's University at Kingston (CA) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008058402-A1 | COMPOUNDS AND METHODS FOR TREATING PROTEIN FOLDING DISORDERS | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2008-05-22 | — | — | WO | disclosed |