Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.47 |
| ▸ | RXRA | P19793 | 2/20 | 0.47 |
| ▸ | RXRB | P28702 | 2/20 | 0.47 |
| ▸ | RXRG | P48443 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 4/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL544470 | 0.91 | MRGPRX4 (0.46) | MRGPRX4RXRARXRBRXRGPTPN1 | |
| SCHEMBL4043788 | 0.84 | MRGPRX4 (0.43) | MRGPRX4RXRARXRBRXRGPTPN1 | |
| SCHEMBL4036485 | 0.84 | PTGER1 (0.47) | MRGPRX4RXRARXRBMCL1XDH | |
| SCHEMBL27751880 | 0.83 | MRGPRX4 (0.41) | MRGPRX4RXRARXRBRXRGPTPN1 | |
| SCHEMBL544311 | 0.78 | MRGPRX4 (0.42) | MRGPRX4RXRARXRBRXRGMCL1 | |
| SCHEMBL27869500 | 0.76 | MRGPRX4 (0.40) | MRGPRX4RXRARXRBRXRGPTPN1 | |
| SCHEMBL4041696 | 0.75 | PTGER1 (0.44) | MRGPRX4MCL1XDHPTGER1 | |
| SCHEMBL6591655 | 0.75 | MRGPRX4 (0.47) | MRGPRX4RXRARXRBRXRGPTPN1 | |
| SCHEMBL544534 | 0.74 | NOTUM (0.56) | MRGPRX4MCL1PTGER1 | |
| SCHEMBL849231 | 0.74 | RXRA (0.72) | MRGPRX4RXRARXRBRXRGPTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2439193-B1 | Derivatives of 5,6-bisaryl-2-pyridine-carboxamide, preparation and use thereof in therapeutics as antagonists of urotensin II receptors | SANOFI SA (FR) | 2014-04-23 | — | — | EP | disclosed |
| EP-2059508-B1 | 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS AS UROTENSIN II RECEPTOR ANTAGONISTS | SANOFI SA (FR) | 2012-04-11 | — | — | EP | disclosed |
| EP-2059508-A1 | 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS AS UROTENSIN II RECEPTOR ANTAGONISTS | Sanofi-Aventis (FR) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008020124-A1 | 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS AS UROTENSIN II RECEPTOR ANTAGONISTS | SANOFI-AVENTIS (FR) | 2008-02-21 | — | — | WO | disclosed |