SCHEMBL4043788

SCHEMBL4043788

Cc1ccccc1-c1ccc(C(=O)O)nc1-c1ccc(C(F)(F)F)c(OCc2ccccc2)c1

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MRGPRX4 Q96LA9 3/20 0.43
RXRA P19793 2/20 0.43
RXRB P28702 2/20 0.43
RXRG P48443 2/20 0.43
PTGER1 P34995 3/20 0.42
MCL1 Q07820 2/20 0.41
XDH P47989 1/20 0.39
DHODH Q02127 2/20 0.39
SYK P43405 1/20 0.39
S1PR1 P21453 2/20 0.39
CTSA P10619 1/20 0.39
P4HTM Q9NXG6 1/20 0.38
PTPN2 P17706 1/20 0.38
PTPN1 P18031 1/20 0.38
PTPN6 P29350 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL544311 0.92 MRGPRX4 (0.42) MRGPRX4RXRARXRBRXRGMCL1
SCHEMBL27751880 0.87 MRGPRX4 (0.41) MRGPRX4RXRARXRBRXRGPTGER1
SCHEMBL4039218 0.85 SLC6A9 (0.43) SYKS1PR1CTSA
SCHEMBL4037851 0.85 PTGER1 (0.47) MRGPRX4PTGER1MCL1XDHDHODH
SCHEMBL4047738 0.84 MRGPRX4 (0.47) MRGPRX4RXRARXRBRXRGPTGER1
SCHEMBL27869500 0.81 MRGPRX4 (0.40) MRGPRX4RXRARXRBRXRGPTGER1
SCHEMBL2491639 0.79 MCL1 (0.43) MRGPRX4PTGER1MCL1DHODHP4HTM
SCHEMBL4041123 0.78 MCL1 (0.46) MRGPRX4PTGER1MCL1XDHCTSA
SCHEMBL544470 0.78 MRGPRX4 (0.46) MRGPRX4RXRARXRBRXRGMCL1
SCHEMBL544584 0.77 NOTUM (0.51) MRGPRX4PTGER1MCL1CTSA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2439193-B1 Derivatives of 5,6-bisaryl-2-pyridine-carboxamide, preparation and use thereof in therapeutics as antagonists of urotensin II receptors SANOFI SA (FR) 2014-04-23 EP disclosed
EP-2059508-B1 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS AS UROTENSIN II RECEPTOR ANTAGONISTS SANOFI SA (FR) 2012-04-11 EP disclosed
EP-2059508-A1 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS AS UROTENSIN II RECEPTOR ANTAGONISTS Sanofi-Aventis (FR) 2009-05-20 EP disclosed
US-7498375-B2 Flame-retardant resin composition POLYPLASTICS CO., LTD. (JP) 2009-03-03 US disclosed
WO-2008020124-A1 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS AS UROTENSIN II RECEPTOR ANTAGONISTS SANOFI-AVENTIS (FR) 2008-02-21 WO disclosed
US-7169836-B2 Mixture of a phosphazene compound, polyphenylene ether , styrene resin and organonitrogen compound POLYPLASTICS CO., LTD (JP) 2007-01-30 US disclosed
US-7115677-B2 Flame-retardant resin composition POLYPLASTICS CO., LTD. (JP) 2006-10-03 US disclosed
US-20060100326-A1 Antistatic agents for resins, antistatic resin compositions, and molding of antistatic resins NIPPPON CHEMICAL INDUSTRIAL CO., LTD (JP) 2006-05-11 US disclosed
US-20040266916-A1 Flame-retardant resin composition POLYPLASTICS CO., LTD. (JP) 2004-12-30 US disclosed
US-20040147646-A1 Flame-retardant resin composition POLYPLASTICS CO., LTD. (JP) 2004-07-29 US disclosed
US-6054209-A DISPERSION OF RESIN BLEND COMPRISING EITHER A STYRENIC POLYMER AND POLYESTER OF POLYAMIDE OR A COMBINATION OF POLYCARBONAATE, ACRYLIC POLYMER AND POLYAMIDE; PACKAGING; EASY TEARING IN ANY DIRECTION; NONSTRETCHING; HIGH TENSILE STRENGTH DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2000-04-25 US disclosed
US-6045902-A COMPRISING OLEFINIC POLYMER, STYRENE POLYMER, COMPATIBILIZING AGENT CONSISTING OF HYDROGENATED OR MODIFIED COPOLYMER OF STYRENIC MONOMER AND CONJUGATED DIENE, AN OLEFINIC COPOLYMER HAVING A CYCLIC OLEFIN UNIT, A CHLORINATED POLYOLEFIN DAICEL CHEMICAL INDUSTRIES LTD. (JP) 2000-04-04 US disclosed
EP-0644226-B1 EASILY TEARABLE FILM AND METHOD OF MANUFACTURING THE SAME DAICEL CHEM (JP) 1999-03-10 EP disclosed
EP-0644226-A1 EASILY TEARABLE FILM AND METHOD OF MANUFACTURING THE SAME DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1995-03-22 EP disclosed