Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.62 |
| ▸ | KIF11 | P52732 | 3/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22925624 | 0.83 | NOTUM (0.62) | NOTUMKIF11NISCHTNKSTNKS2 | |
| SCHEMBL452337 | 0.77 | NOTUM (0.68) | NOTUMRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL789358 | 0.77 | NOTUM (0.68) | NOTUMMIF | |
| SCHEMBL9782150 | 0.77 | NOTUM (1.00) | NOTUMRAB9ANPC1KDM4ELMNA | |
| SCHEMBL20370831 | 0.76 | NOTUM (0.67) | NOTUMKIF11RAB9ANPC1NISCH | |
| SCHEMBL181974 | 0.76 | NOTUM (0.67) | NOTUMRAB9ANPC1KDM4ELMNA | |
| SCHEMBL31178428 | 0.74 | NOTUM (0.65) | NOTUMLMNATP53 | |
| SCHEMBL11023401 | 0.72 | NOTUM (0.62) | NOTUMRAB9ANPC1KDM4ETP53 | |
| SCHEMBL11717156 | 0.68 | NOTUM (0.56) | NOTUMTP53 | |
| SCHEMBL2224968 | 0.67 | NOTUM (0.50) | NOTUMRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120100989-A1 | 3-Aryl-4-(2-thienylmethylene)isoxazol-5(4H)-ones as Fungicides | BAYER CROPSCIENCE AG (DE) | 2012-04-26 | — | — | US | disclosed |
| WO-2011161035-A1 | 3-ARYL-4-(2-THIENYLMETHYLENE)-ISOXAZOL-5(4H)-ONES AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2011-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120100989-A1 | 3-Aryl-4-(2-thienylmethylene)isoxazol-5(4H)-ones as Fungicides | CYP4X1, CYP4Z1, TH | NOTUM 1620/4885KIF11 3421/4885PRKDC 837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.