Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14454102 | 0.86 | POLB (0.50) | CYP19A1TDP1KMT2AMEN1TSHR | |
| SCHEMBL8828553 | 0.86 | CD44 (0.43) | CYP19A1TDP1L3MBTL1SMN1; SMN2HPGD | |
| SCHEMBL11530038 | 0.82 | CYP19A1 (0.52) | CYP19A1TDP1ALDH1A1EGFRSRC | |
| SCHEMBL4163438 | 0.82 | CA12 (0.53) | CYP19A1SMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL28269320 | 0.82 | TDP1 (0.39) | CYP19A1TDP1L3MBTL1HPGDALDH1A1 | |
| SCHEMBL31345289 | 0.80 | NR4A2 (0.45) | CYP19A1L3MBTL1HPGDALDH1A1KMT2A | |
| SCHEMBL20812009 | 0.79 | CNR2 (0.41) | TDP1L3MBTL1HPGDALDH1A1KMT2A | |
| SCHEMBL38654404 | 0.77 | CYP19A1 (0.40) | CYP19A1SMN1; SMN2HPGDNPC1ALDH1A1 | |
| SCHEMBL629579 | 0.76 | THRB (0.56) | CYP19A1TDP1L3MBTL1SMN1; SMN2HPGD | |
| SCHEMBL1004853 | 0.76 | HPGD (0.46) | L3MBTL1SMN1; SMN2HPGDNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066647-A1 | BENZOXAZOLES AND OXAZOLOPYRIDINES BEING USEFUL AS JANUS KINASES INHIBITORS | Novartis AG (CH) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008031594-A1 | BENZOXAZOLES AND OXAZOLOPYRIDINES BEING USEFUL AS JANUS KINASES INHIBITORS | NOVARTIS AG (CH) | 2008-03-20 | — | — | WO | disclosed |