Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.64 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3950222 | 0.88 | EGFR (0.81) | EGFRFGFR1FGFR2FGFR3 | |
| SCHEMBL3948199 | 0.86 | EGFR (0.68) | EGFRFGFR1FGFR2FGFR3 | |
| SCHEMBL4048149 | 0.80 | EGFR (0.56) | EGFRTNK2 | |
| SCHEMBL2387612 | 0.80 | MET (0.62) | EGFRTNK2FGFR1FGFR2FGFR3 | |
| SCHEMBL3950078 | 0.80 | EGFR (0.72) | EGFRTNK2FGFR1FGFR2FGFR3 | |
| SCHEMBL3949889 | 0.79 | EGFR (1.00) | EGFRFGFR1FGFR2FGFR3 | |
| SCHEMBL2385241 | 0.78 | FGFR1 (0.57) | TNK2FGFR1FGFR2FGFR3 | |
| SCHEMBL24288969 | 0.78 | FGFR1 (0.63) | TNK2FGFR1FGFR2FGFR3 | |
| SCHEMBL4042780 | 0.77 | EGFR (0.68) | EGFRFGFR1FGFR2FGFR3 | |
| SCHEMBL4047011 | 0.76 | EGFR (0.56) | EGFRTNK2FGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |