Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.56 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13942249 | 0.85 | EGFR (0.74) | EGFR | |
| SCHEMBL4046378 | 0.84 | EGFR (0.60) | EGFRMET | |
| SCHEMBL2388528 | 0.82 | AXL (0.54) | EGFRTNK2MET | |
| SCHEMBL4048129 | 0.80 | EGFR (0.64) | EGFRTNK2 | |
| SCHEMBL22781402 | 0.79 | TNK2 (0.42) | EGFRTNK2KDRPIK3CAMET | |
| SCHEMBL21266833 | 0.79 | TNK2 (0.42) | EGFRTNK2KDRPIK3CAMET | |
| SCHEMBL3949724 | 0.78 | TNK2 (0.43) | EGFRTNK2PIK3CAMET | |
| SCHEMBL3946717 | 0.77 | IRAK4 (0.43) | EGFRTNK2KDRPIK3CA | |
| SCHEMBL3952265 | 0.77 | IRAK4 (0.48) | EGFRTNK2 | |
| SCHEMBL2799660 | 0.75 | MET (0.41) | TNK2KDRPIK3CAMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |