Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.44 |
| ▸ | CLK2 | P49760 | 2/20 | 0.38 |
| ▸ | CLK3 | P49761 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | MTOR | P42345 | 3/20 | 0.37 |
| ▸ | ATR | Q13535 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.36 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.36 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.36 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4052001 | 0.92 | GPR119 (0.42) | GPR119CLK2CLK3DYRK1AMCHR1 | |
| SCHEMBL13690402 | 0.91 | GPR119 (0.46) | GPR119CLK2CLK3DYRK1AMCHR1 | |
| SCHEMBL13690502 | 0.86 | GPR119 (0.41) | GPR119CLK2CLK3DYRK1A | |
| SCHEMBL13690775 | 0.86 | NAMPT (0.40) | GPR119MCHR1MTORATR | |
| SCHEMBL4053026 | 0.85 | GPR119 (0.50) | GPR119CLK2CLK3DYRK1AGSK3B | |
| SCHEMBL13690516 | 0.85 | GPR119 (0.60) | GPR119 | |
| SCHEMBL13690785 | 0.84 | ATR (0.48) | MCHR1PIK3CAMTORATRPIK3CG | |
| SCHEMBL13690488 | 0.84 | GPR119 (0.53) | GPR119 | |
| SCHEMBL13690604 | 0.82 | RXFP1 (0.41) | MCHR1 | |
| SCHEMBL13690494 | 0.81 | TSHR (0.41) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |