Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 18/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | CLK3 | P49761 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP7 | P09237 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4052001 | 0.87 | GPR119 (0.42) | GPR119CLK2CLK3DYRK1A | |
| SCHEMBL4048220 | 0.86 | GPR119 (0.44) | GPR119CLK2CLK3DYRK1A | |
| SCHEMBL13690466 | 0.86 | EPHX2 (0.35) | GPR119 | |
| SCHEMBL4053026 | 0.84 | GPR119 (0.50) | GPR119CLK2CLK3DYRK1A | |
| SCHEMBL13690516 | 0.84 | GPR119 (0.60) | GPR119 | |
| SCHEMBL13690488 | 0.83 | GPR119 (0.53) | GPR119 | |
| SCHEMBL13690402 | 0.78 | GPR119 (0.46) | GPR119CLK2CLK3DYRK1A | |
| SCHEMBL4058199 | 0.78 | GPR119 (0.51) | GPR119 | |
| SCHEMBL4048254 | 0.77 | GPR119 (0.46) | GPR119 | |
| SCHEMBL3988664 | 0.77 | GPR119 (0.46) | GPR119CLK2CLK3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |