Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 12/20 | 0.56 |
| ▸ | CTSS | P25774 | 3/20 | 0.44 |
| ▸ | CTSV | O60911 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4044248 | 0.95 | CTSK (0.60) | CTSKCTSSCTSLNPC1RAB9A | |
| SCHEMBL4051972 | 0.95 | CTSK (0.54) | CTSKCTSSCTSVCTSLCCR1 | |
| SCHEMBL4045482 | 0.94 | CTSK (0.54) | CTSKCTSSCTSVCTSLCCR1 | |
| SCHEMBL4043955 | 0.91 | CTSK (0.58) | CTSKCTSSCTSVCTSLCCR1 | |
| SCHEMBL4042238 | 0.90 | CTSK (0.70) | CTSKCTSSCTSVCTSLCCR1 | |
| SCHEMBL4047208 | 0.89 | CTSK (0.71) | CTSKCTSSCTSVCTSLCCR1 | |
| SCHEMBL4045165 | 0.89 | CTSK (0.61) | CTSKCTSSCTSVCTSLCCR1 | |
| SCHEMBL4040326 | 0.88 | CTSK (0.56) | CTSKCTSSCTSVCTSLCCR1 | |
| SCHEMBL4050846 | 0.87 | CTSK (0.64) | CTSKCTSSCTSVCTSLCCR1 | |
| SCHEMBL4041020 | 0.87 | CTSK (0.54) | CTSKCTSSCTSLCCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |