Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4052299 | 0.89 | BRAF (0.40) | BRAFKDRALDH1A1KDM4EMAPT | |
| SCHEMBL4048686 | 0.87 | BRAF (0.39) | BRAFALDH1A1HPGDHTTMEN1 | |
| SCHEMBL4052889 | 0.87 | BRAF (0.47) | BRAFMAPK14MAPK13RAF1MAPK12 | |
| SCHEMBL4047106 | 0.85 | BRAF (0.51) | BRAFKDRMAPTTDP1MAPK14 | |
| SCHEMBL4045295 | 0.82 | BRAF (0.46) | BRAFKDRALDH1A1KDM4EMAPT | |
| SCHEMBL4054055 | 0.82 | BRAF (0.49) | BRAFKDRALDH1A1KDM4EMAPT | |
| SCHEMBL4047970 | 0.77 | — | — | |
| SCHEMBL4046191 | 0.75 | NPC1 (0.53) | BRAFKDRALDH1A1MAPTLMNA | |
| SCHEMBL4055203 | 0.74 | BRAF (0.46) | BRAFKDRALDH1A1MAPTTDP1 | |
| SCHEMBL4054162 | 0.72 | BRAF (0.49) | BRAFMAPK14MAPK13RAF1MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009108827-A1 | FUSED TRICYCLIC PYRAZOLO[1, 5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | WYETH (US) | 2009-09-03 | — | — | WO | claimed |