Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.46 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047106 | 0.86 | BRAF (0.51) | BRAFKDRMAPTTDP1MAPK14 | |
| SCHEMBL4049202 | 0.82 | BRAF (0.39) | BRAFCYP46A1KDRBTKKDM4E | |
| SCHEMBL4048461 | 0.82 | BRAF (0.49) | BRAFKDRKDM4ELMNAHSD17B10 | |
| SCHEMBL4048686 | 0.75 | BRAF (0.39) | BRAFMAPK14ALDH1A1 | |
| SCHEMBL4054162 | 0.75 | BRAF (0.49) | BRAFMAPK14 | |
| SCHEMBL4046191 | 0.75 | NPC1 (0.53) | BRAFKDRLMNAMAPTTDP1 | |
| SCHEMBL4055203 | 0.72 | BRAF (0.46) | BRAFKDRMAPTTDP1MAPK14 | |
| SCHEMBL4054055 | 0.72 | BRAF (0.49) | BRAFKDRKDM4ELMNAHSD17B10 | |
| SCHEMBL4052299 | 0.71 | BRAF (0.40) | BRAFKDRKDM4EHSD17B10MAPT | |
| SCHEMBL4052889 | 0.71 | BRAF (0.47) | BRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009108827-A1 | FUSED TRICYCLIC PYRAZOLO[1, 5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | WYETH (US) | 2009-09-03 | — | — | WO | claimed |
| WO-2009108827-A1 | FUSED TRICYCLIC PYRAZOLO[1, 5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | WYETH (US) | 2009-09-03 | — | — | WO | disclosed |