Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 12/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4054055 | 0.81 | BRAF (0.49) | BRAFKDRMAPK14MAPTTDP1 | |
| SCHEMBL4046191 | 0.75 | NPC1 (0.53) | BRAFKDRMAPK14MAPTTDP1 | |
| SCHEMBL4048461 | 0.74 | BRAF (0.49) | BRAFKDRMAPK14MAPTTDP1 | |
| SCHEMBL4047106 | 0.73 | BRAF (0.51) | BRAFKDRMAPK14MAPTTDP1 | |
| SCHEMBL4049173 | 0.73 | BRAF (0.37) | BRAF | |
| SCHEMBL4047410 | 0.72 | BRAF (0.46) | BRAFMAPK14MAPTALDH1A1DCTPP1 | |
| SCHEMBL4045295 | 0.72 | BRAF (0.46) | BRAFKDRMAPK14MAPTTDP1 | |
| SCHEMBL1017360 | 0.70 | BRAF (0.63) | BRAFKDRMAPK14MAPTTDP1 | |
| SCHEMBL1014169 | 0.66 | BRAF (0.68) | BRAFMAPK14MAPTTDP1ROCK1 | |
| SCHEMBL4052299 | 0.65 | BRAF (0.40) | BRAFKDRMAPK14MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009108827-A1 | FUSED TRICYCLIC PYRAZOLO[1, 5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | WYETH (US) | 2009-09-03 | — | — | WO | disclosed |