Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 16/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.41 |
| ▸ | HPGD | P15428 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 5/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.32 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045731 | 0.89 | ALDH1A1 (0.45) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL4049208 | 0.87 | IDH1 (0.39) | ALDH1A1KDM4EHPGDTSHRIDH1 | |
| SCHEMBL4053983 | 0.86 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL4048407 | 0.72 | KDM4E (0.32) | ALDH1A1KDM4EHPGDIDH1 | |
| SCHEMBL4044811 | 0.70 | KDM4E (0.39) | ALDH1A1KDM4EHPGDMAPTHTT | |
| SCHEMBL5013044 | 0.68 | ALDH1A1 (0.71) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL4044801 | 0.68 | PDE4A (0.37) | ALDH1A1KDM4EHPGDHSD17B10NPSR1 | |
| SCHEMBL5012401 | 0.68 | ALDH1A1 (0.69) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL5015889 | 0.67 | ALDH1A1 (0.58) | ALDH1A1KDM4EHPGDHSD17B10NPSR1 | |
| SCHEMBL4922970 | 0.67 | ALDH1A1 (0.69) | ALDH1A1KDM4EHPGDHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819710-B1 | NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES | ALMIRALL LAB (ES) | 2009-03-11 | — | — | EP | disclosed |
| US-20090029955-A1 | Pyridothienopyrimidine Derivatives | ALMIRALL PRODESFARMA S.A. (ES) | 2009-01-29 | — | — | US | disclosed |
| EP-1819710-A1 | NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES | Laboratorios Almirall, S.A. (ES) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006058724-A1 | NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES | LABORATORIOS ALMIRALL, S.A. (ES) | 2006-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029955-A1 | Pyridothienopyrimidine Derivatives | PNPO, PDE4A, DPYD | ALDH1A1 391/4885KDM4E 1600/4885HPGD 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.