Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | HPGD | P15428 | 7/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047943 | 0.84 | PDE4A (0.56) | PDE4APDE4BPDE4DKDM4EALDH1A1 | |
| SCHEMBL4052788 | 0.81 | PDE4B (0.64) | PDE4APDE4BPDE4DKDM4EALDH1A1 | |
| SCHEMBL4045649 | 0.80 | KDM4E (0.55) | PDE4APDE4BPDE4DKDM4EALDH1A1 | |
| SCHEMBL4044859 | 0.77 | ALDH1A1 (0.74) | PDE4APDE4BPDE4DKDM4EALDH1A1 | |
| SCHEMBL4046467 | 0.76 | KDM4E (0.61) | PDE4APDE4BPDE4DKDM4EALDH1A1 | |
| SCHEMBL4046040 | 0.76 | HPGD (0.74) | PDE4APDE4BPDE4DKDM4EALDH1A1 | |
| SCHEMBL5245426 | 0.75 | KDM4E (0.61) | PDE4APDE4BPDE4DKDM4EALDH1A1 | |
| SCHEMBL4047007 | 0.74 | PDE4B (0.70) | PDE4APDE4BPDE4DKDM4EALDH1A1 | |
| SCHEMBL4047111 | 0.74 | KDM4E (0.60) | PDE4APDE4BPDE4DKDM4EALDH1A1 | |
| SCHEMBL4047590 | 0.74 | PDE4B (0.69) | PDE4APDE4BPDE4DKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819710-B1 | NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES | ALMIRALL LAB (ES) | 2009-03-11 | — | — | EP | disclosed |
| EP-1819710-A1 | NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES | Laboratorios Almirall, S.A. (ES) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006058724-A1 | NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES | LABORATORIOS ALMIRALL, S.A. (ES) | 2006-06-08 | — | — | WO | disclosed |