Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 2/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.41 |
| ▸ | MLNR | O43193 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.39 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4212875 | 0.81 | CHRM3 (0.55) | KCNH2CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL4048497 | 0.81 | CHRM2 (0.49) | MGLLCHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL4049340 | 0.80 | MGLL (0.43) | MGLLFAAHCHRM3CHRM4PTGDR2 | |
| SCHEMBL28883115 | 0.75 | KCNH2 (0.81) | KCNH2CHRM2CHRM1CHRM3 | |
| SCHEMBL28883114 | 0.75 | KCNH2 (0.81) | KCNH2CHRM2CHRM1CHRM3 | |
| SCHEMBL27034618 | 0.74 | DPP4 (0.53) | CHRM2CHRM1CHRM4PTGDR2 | |
| SCHEMBL5101569 | 0.74 | MLNR (0.76) | MGLLMCHR1CHRM4MLNR | |
| SCHEMBL2765877 | 0.74 | MLNR (0.76) | MGLLMCHR1CHRM4MLNR | |
| SCHEMBL3400992 | 0.74 | CHRM3 (0.50) | KCNH2CHRM2CHRM1CHRM3 | |
| SCHEMBL4088121 | 0.74 | CHRM4 (0.48) | MGLLFAAHCHRM1CHRM4PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725236-A4 | NOVEL M3 MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2009-05-13 | — | — | EP | disclosed |
| EP-1725236-A1 | NOVEL M3 MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005087236-A1 | NOVEL M3 MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2005-09-22 | — | — | WO | disclosed |