Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.53 |
| ▸ | NSD2 | O96028 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 5/20 | 0.47 |
| ▸ | DRD3 | P35462 | 5/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | FADS1 | O60427 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | CTSG | P08311 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2941206 | 0.82 | F10 (0.50) | PIK3CDHTR1APRKDCF10 | |
| SCHEMBL16705239 | 0.80 | NSD2 (0.64) | NSD2DRD2DRD3KCNH2ALOX5 | |
| SCHEMBL29519746 | 0.79 | NSD2 (0.54) | NSD2DRD2DRD3KCNH2ALOX5 | |
| SCHEMBL19693904 | 0.79 | NSD2 (0.54) | NSD2DRD2DRD3KCNH2ALOX5 | |
| SCHEMBL20124865 | 0.79 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CGPIK3CBF10 | |
| SCHEMBL29740650 | 0.79 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CGPIK3CBF10 | |
| SCHEMBL2940366 | 0.78 | MAP4K1 (0.50) | PIK3CDDRD2DRD3PIK3CAPIK3CG | |
| SCHEMBL1438679 | 0.78 | PIK3CD (0.46) | PIK3CDDRD2DRD3KCNH2PIK3CA | |
| SCHEMBL20502398 | 0.78 | ALDH1A1 (0.48) | PIK3CDPIK3CAPIK3CGALOX5PIK3CB | |
| SCHEMBL13097259 | 0.78 | F10 (0.49) | PIK3CDPIK3CAPIK3CGPIK3CBF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029582-A1 | ISOINDOLIN-1-ONE-, ISOINDOLIN-3-ONE- AND ISOINDOLIN-1,3-DIONE-DERIVATIVES AND USE THEREOF | Bayer HealthCare AG (DE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007137790-A1 | ISOINDOLIN-1-ONE-, ISOINDOLIN-3-ONE- AND ISOINDOLIN-1,3-DIONE-DERIVATIVES AND USE THEREOF | BAYER HEALTHCARE AG (DE) | 2007-12-06 | — | — | WO | disclosed |
| WO-2007137790-A1 | ISOINDOLIN-1-ONE-, ISOINDOLIN-3-ONE- AND ISOINDOLIN-1,3-DIONE-DERIVATIVES AND USE THEREOF | BAYER HEALTHCARE AG (DE) | 2007-12-06 | — | — | WO | disclosed |