Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 17/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047243 | 0.77 | BRAF (0.38) | BRAF | |
| SCHEMBL4046191 | 0.61 | NPC1 (0.53) | BRAFCYP3A4 | |
| SCHEMBL1016142 | 0.59 | BRAF (0.64) | BRAF | |
| SCHEMBL31300130 | 0.58 | MAPT (0.49) | CYP3A4 | |
| SCHEMBL4052299 | 0.58 | BRAF (0.40) | BRAF | |
| SCHEMBL4048461 | 0.57 | BRAF (0.49) | BRAFCYP3A4 | |
| SCHEMBL4047106 | 0.57 | BRAF (0.51) | BRAF | |
| SCHEMBL4045295 | 0.56 | BRAF (0.46) | BRAFCYP11B1 | |
| SCHEMBL1014169 | 0.55 | BRAF (0.68) | BRAF | |
| SCHEMBL4052889 | 0.54 | BRAF (0.47) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009108827-A1 | FUSED TRICYCLIC PYRAZOLO[1, 5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | WYETH (US) | 2009-09-03 | — | — | WO | disclosed |