Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 11/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4044782 | 0.81 | EGFR (0.61) | ATRFGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4041097 | 0.80 | EGFR (0.47) | ATRFGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4047639 | 0.77 | EGFR (0.44) | ATRFGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4044231 | 0.77 | EGFR (0.78) | ATRFGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4049905 | 0.77 | EGFR (0.64) | ATRFGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4042032 | 0.75 | EGFR (0.62) | ATRFGFR1FGFR2FGFR3EGFR | |
| SCHEMBL2680570 | 0.74 | SLC2A1 (0.50) | FGFR1FGFR2FGFR3KDRIKBKE | |
| SCHEMBL16848370 | 0.73 | PIM1 (0.52) | FGFR1FGFR2FGFR3KDRIKBKE | |
| SCHEMBL18781303 | 0.72 | FGFR1 (0.53) | ATRFGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4045589 | 0.72 | EGFR (0.56) | ATRFGFR1FGFR2FGFR3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |