Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 14/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041097 | 0.91 | EGFR (0.47) | EGFRBMPR1AACVRL1ACVR1ATR | |
| SCHEMBL4045589 | 0.85 | EGFR (0.56) | EGFRBMPR1AACVRL1ACVR1ATR | |
| SCHEMBL4042032 | 0.79 | EGFR (0.62) | EGFRATRFGFR1FGFR2FGFR3 | |
| SCHEMBL4049196 | 0.77 | ATR (0.51) | EGFRATRFGFR1FGFR2FGFR3 | |
| SCHEMBL4044782 | 0.75 | EGFR (0.61) | EGFRATRFGFR1FGFR2FGFR3 | |
| SCHEMBL4044231 | 0.74 | EGFR (0.78) | EGFRATRFGFR1FGFR2FGFR3 | |
| SCHEMBL4049905 | 0.74 | EGFR (0.64) | EGFRATRFGFR1FGFR2FGFR3 | |
| SCHEMBL4405948 | 0.72 | BMPR1A (0.42) | BMPR1AACVRL1ACVR1ATRFGFR1 | |
| SCHEMBL4047605 | 0.71 | EGFR (0.62) | EGFRATRFGFR1FGFR2FGFR3 | |
| SCHEMBL4043371 | 0.70 | ATR (0.78) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |