Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.38 |
| ▸ | PRMT8 | Q9NR22 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.34 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4395015 | 0.85 | ACE2 (0.61) | ACE2KDM1ACARM1PRMT6PRMT8 | |
| SCHEMBL18024085 | 0.84 | ACE2 (0.50) | ACE2KDM1ACARM1PRMT6PRMT8 | |
| SCHEMBL7730804 | 0.79 | ACE2 (0.48) | ACE2KDM1ACARM1PRMT6PRMT8 | |
| SCHEMBL22416389 | 0.77 | ACE2 (0.52) | ACE2KDM1ACARM1PRMT6PRMT8 | |
| SCHEMBL18871374 | 0.77 | ACE2 (0.46) | ACE2KDM1ACARM1PRMT6PRMT8 | |
| SCHEMBL4054338 | 0.77 | ALDH1A1 (0.41) | ACE2KDM1AHTR4ALDH1A1TSHR | |
| SCHEMBL19966100 | 0.76 | CARM1 (0.41) | ACE2KDM1ACARM1PRMT6PRMT8 | |
| SCHEMBL18427293 | 0.76 | CARM1 (0.52) | ACE2KDM1ACARM1PRMT6PRMT8 | |
| SCHEMBL22416388 | 0.76 | ACE2 (0.83) | ACE2KDM1ACARM1PRMT6PRMT8 | |
| SCHEMBL18024002 | 0.76 | ACE2 (0.50) | ACE2KDM1ACARM1PRMT6PRMT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038264-A1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008000645-A1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |