Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | LOX | P28300 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11249172 | 0.79 | CARM1 (0.54) | ALDH1A1KDM1AMEN1KMT2ATSHR | |
| SCHEMBL14500308 | 0.78 | ALDH1A1 (0.43) | ALDH1A1KDM1AMEN1KMT2ATSHR | |
| SCHEMBL1098206 | 0.77 | KDM1A (0.45) | ALDH1A1KDM1AMEN1KMT2ATSHR | |
| SCHEMBL4049413 | 0.77 | ACE2 (0.46) | ALDH1A1KDM1AACE2TSHRHTR4 | |
| SCHEMBL12607000 | 0.75 | MEN1 (0.44) | ALDH1A1KDM1AMEN1KMT2ATSHR | |
| SCHEMBL16601547 | 0.75 | CACNA1H (0.43) | ALDH1A1KDM1AMEN1KMT2ATSHR | |
| SCHEMBL9836417 | 0.74 | ALDH1A1 (0.52) | ALDH1A1KDM1AMEN1KMT2ATSHR | |
| SCHEMBL1100792 | 0.73 | KDM1A (0.43) | ALDH1A1KDM1AKDM4ETDP1SMN1; SMN2 | |
| SCHEMBL10262951 | 0.72 | MEN1 (0.46) | ALDH1A1KDM1AMEN1KMT2AKDM4E | |
| SCHEMBL21730437 | 0.72 | ALDH1A1 (0.40) | ALDH1A1KDM1AMEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038264-A1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008000645-A1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |