Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 10/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14263753 | 1.00 | PNMT (0.44) | PNMTADRA2AADRA2BADRA2CTDP2 | |
| SCHEMBL14263752 | 0.79 | PNMT (0.38) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL14263756 | 0.68 | PSEN1 (0.58) | — | |
| SCHEMBL22271652 | 0.67 | PNMT (0.55) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL5620372 | 0.67 | PNMT (0.55) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL1948741 | 0.67 | PNMT (0.55) | PNMTADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL1642104 | 0.66 | PNMT (0.54) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL29370265 | 0.65 | PNMT (0.57) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL2728205 | 0.65 | PNMT (0.57) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL4551781 | 0.65 | PNMT (0.57) | PNMTADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503998-B1 | HETEROARYL SUBSTITUTED SPIROCYCLIC SUFAMIDES FOR INHIBITION OF GAMMA SECRETASE | MERCK SHARP & DOHME (GB) | 2009-07-01 | — | — | EP | disclosed |
| US-7282513-B2 | Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase | MERCK SHARP & DOHME LIMITED (GB) | 2007-10-16 | — | — | US | disclosed |