Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.55 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAT2A | P31153 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14323999 | 0.92 | ADORA3 (0.58) | ADORA3MARK4ADORA1NPC1RAB9A | |
| SCHEMBL406009 | 0.89 | ADORA3 (0.55) | ADORA3MARK4ADORA1MAT2APOLB | |
| SCHEMBL14323731 | 0.88 | ADORA3 (0.54) | ADORA3MARK4ADORA1KDM4EALDH1A1 | |
| SCHEMBL463580 | 0.85 | ADORA3 (0.51) | ADORA3MARK4ADORA1MAT2AMAPT | |
| SCHEMBL14323629 | 0.85 | ADORA3 (0.76) | ADORA3ADORA1KDM4EALDH1A1MAT2A | |
| SCHEMBL23037523 | 0.82 | ADORA3 (0.54) | ADORA3ADORA1KDM4EALDH1A1MAT2A | |
| SCHEMBL15652719 | 0.79 | PTGS2 (0.53) | ADORA3ADORA1KDM4EMAT2AMEN1 | |
| SCHEMBL4100979 | 0.78 | ADORA3 (0.47) | ADORA3ADORA1NPC1RAB9AKDM4E | |
| SCHEMBL404931 | 0.76 | POLB (0.44) | NPC1RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL23037496 | 0.75 | ADORA3 (0.47) | ADORA3ADORA1KDM4EALDH1A1MAT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065187-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | ALCON RESEARCH, LTD (US) | 2012-03-15 | — | — | US | disclosed |
| US-20110257137-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2011-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065187-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | HRH4, HRH3, HRH2 | ADORA3 277/4885MARK4 2472/4885ADORA1 273/4885 |
| US-20110257137-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | HRH4, HRH3, HRH2 | ADORA3 277/4885MARK4 2472/4885ADORA1 273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.