SCHEMBL4050144

SCHEMBL4050144

C=CC[Si](CC=C)(CC=C)[N]c1c(F)ccc2ccccc12

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.36
L3MBTL1 Q9Y468 3/20 0.36
KDM4E B2RXH2 3/20 0.36
MAPK1 P28482 2/20 0.36
NPC1 O15118 2/20 0.36
HPRT1 P00492 2/20 0.34
TDP1 Q9NUW8 4/20 0.33
HPGD P15428 2/20 0.33
THRB P10828 2/20 0.33
ALDH1A1 P00352 4/20 0.32
TSHR P16473 2/20 0.32
HSD17B10 Q99714 2/20 0.32
CYP2A6 P11509 1/20 0.32
ALOX12 P18054 2/20 0.32
CA12 O43570 1/20 0.32
CA3 P07451 1/20 0.32
CA4 P22748 1/20 0.32
CA6 P23280 1/20 0.32
CA5A P35218 1/20 0.32
CA7 P43166 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4042091 0.70 RAB9A (0.33) NPC1TDP1SMN1; SMN2GAA
SCHEMBL301407 0.67 HSD17B10 (0.40) MAPTL3MBTL1KDM4EHPRT1TDP1
SCHEMBL15302230 0.62 KMT2A (0.36) MAPTL3MBTL1KDM4EMAPK1TDP1
SCHEMBL15302485 0.62 KMT2A (0.36) MAPTL3MBTL1KDM4EMAPK1TDP1
SCHEMBL15301978 0.62 KMT2A (0.36) MAPTL3MBTL1KDM4EMAPK1TDP1
SCHEMBL31530497 0.61 KMT2A (0.37) MAPTL3MBTL1KDM4EMAPK1HPRT1
SCHEMBL5950474 0.61 ALDH1A1 (0.50) MAPTL3MBTL1KDM4EMAPK1NPC1
SCHEMBL6641451 0.60 HSD17B10 (0.44) MAPTL3MBTL1KDM4EHPRT1TDP1
SCHEMBL301406 0.60 ALDH1A1 (0.39) KDM4EHPRT1TDP1HPGDALDH1A1
SCHEMBL27990175 0.60 HPRT1 (0.40) MAPTL3MBTL1KDM4EMAPK1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1406761-B1 POLYOLEFINS MADE BY CATALYST COMPRISING A NONCOORDINATING ANION AND ARTICLES COMPRISING THEM EXXONMOBIL CHEM PATENTS INC (US) 2016-11-02 EP disclosed
US-7511104-B2 Polyolefins made by catalyst comprising a noncoordinating anion and articles comprising them EXXONMOBIL CHEMICAL PATENTS INC. (US) 2009-03-31 US disclosed
US-20050123778-A1 Polyolefins made by catalyst comprising a noncoordinating anion and articles comprising them EXXONMOBIL CHEMICAL PATENTS INC. 2005-06-09 US disclosed
EP-1406761-A2 POLYOLEFINS MADE BY CATALYST COMPRISING A NONCOORDINATING ANION AND ARTICLES COMPRISING THEM ExxonMobil Chemical Patents, Inc., A Corporation of the State of Delaware (US) 2004-04-14 EP disclosed
WO-2003000740-A2 POLYOLEFINS MADE BY CATALYST COMPRISING A NONCOORDINATING ANION AND ARTICLES COMPRISING THEM EXXONMOBIL CHEMICAL PATENTS INC. (US) 2003-01-03 WO disclosed