SCHEMBL4050187

SCHEMBL4050187

C=CC(F)CC(=O)O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7573454 0.76
SCHEMBL4280331 0.72 SLC22A6 (0.43)
SCHEMBL11140563 0.72 SLC22A6 (0.43)
Bicarbonate SCHEMBL27528810 0.72 TSHR (0.35)
SCHEMBL7203018 0.71 TSHR (0.53)
SCHEMBL3129296 0.70
SCHEMBL4610511 0.70
SCHEMBL415931 0.70
SCHEMBL4406594 0.70
SCHEMBL7416325 0.68

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1521738-B1 METHOD FOR MAKING NITRILE COMPOUNDS FROM ETHYLENICALLY UNSATURATED COMPOUNDS INVISTA TEXTILES (U K ) LTD (GB) 2017-11-01 EP disclosed
EP-1521736-B1 MAKING NITRILE COMPOUNDS FROM ETHYLENICALLY UNSATURATED COMPOUNDS INVISTA TECHNOLOGIES SARL (CH) 2017-09-13 EP disclosed
US-7531682-B2 Method for making nitrile compounds from ethylenically unsaturated compounds RHODIA POLYAMIDE INTERMEDIATES (FR) 2009-05-12 US disclosed
US-7442825-B2 Making nitrile compounds from ethylenically unsaturated compounds RHODIA POLYAMIDE INTERMEDIATES (FR) 2008-10-28 US disclosed
US-7253298-B2 Hydrocyanating an unsaturated aliphatic nitrile, or a linear pentenenitrile in a liquid medium with hydrogen cyanide in the presence of a Nickel catalyst with an triaryl phosphite ligand; isomerization RHODIA POLYAMIDE INTERMEDIATES (FR) 2007-08-07 US disclosed
US-20060128980-A1 Method for making nitrile compounds from ethylenically unsaturated compounds INVISTA NORTH AMERICA SARL 2006-06-15 US disclosed
US-20060100455-A1 Hydrocyanating an unsaturated aliphatic nitrile, or a linear pentenenitrile in a liquid medium with hydrogen cyanide in the presence of a Nickel catalyst with an triaryl phosphite ligand; isomerization INVISTA NORTH AMERICA SARL 2006-05-11 US disclosed
US-20060052624-A1 Making nitrile compounds from ethylenically unsaturated compounds INVISTA NORTH AMERICA SARL 2006-03-09 US disclosed
EP-1521736-A1 MAKING NITRILE COMPOUNDS FROM ETHYLENICALLY UNSATURATED COMPOUNDS Rhodia Polyamide Intermediates (FR) 2005-04-13 EP disclosed
EP-1521738-A2 METHOD FOR MAKING NITRILE COMPOUNDS FROM ETHYLENICALLY UNSATURATED COMPOUNDS RHODIA POLYAMIDE INTERMEDIATES (FR) 2005-04-13 EP disclosed
WO-2004007508-A2 NITRILE PRODUCTION FROM ETHYLENICALLY UNSATURATED COMPOUNDS RHODIA POLYAMIDE INTERMEDIATES (FR) 2004-01-22 WO disclosed
WO-2004007435-A2 METHOD FOR MAKING NITRILE COMPOUNDS FROM ETHYLENICALLY UNSATURATED COMPOUNDS RHODIA POLYAMIDE INTERMEDIATES (FR) 2004-01-22 WO disclosed
WO-2004007432-A1 MAKING NITRILE COMPOUNDS FROM ETHYLENICALLY UNSATURATED COMPOUNDS RHODIA POLYAMIDE INTERMEDIATES (FR) 2004-01-22 WO disclosed
WO-2003068729-A1 METHOD OF PRODUCING NITRILE COMPOUNDS FROM COMPOUNDS WITH ETHYLENIC UNSATURATION RHODIA POLYAMIDE INTERMEDIATES (FR) 2003-08-21 WO disclosed
WO-2003031392-A1 METHOD FOR TRANSFORMING ETHYLENICALLY UNSATURATED COMPOUNDS INTO NITRILES AND BRANCHED NITRILES INTO LINEAR NITRILES RHODIA POLYAMIDE INTERMEDIATES (FR) 2003-04-17 WO disclosed