Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LPO | P22079 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23147760 | 0.86 | KDM4E (0.36) | KDM4EMAPTALDH1A1NPC1LPO | |
| SCHEMBL29721744 | 0.86 | KDM4E (0.36) | KDM4EMAPTALDH1A1NPC1LPO | |
| SCHEMBL29680739 | 0.85 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1KMT2AMEN1 | |
| SCHEMBL24528657 | 0.85 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1KMT2AMEN1 | |
| SCHEMBL1513230 | 0.77 | PARP1 (0.42) | ALDH1A1LPOSLC22A12KMT2AMEN1 | |
| SCHEMBL29721895 | 0.75 | LPO (0.33) | KDM4EALDH1A1NOTUMLPOSLC22A12 | |
| SCHEMBL23147725 | 0.75 | LPO (0.33) | KDM4EALDH1A1NOTUMLPOSLC22A12 | |
| SCHEMBL4768186 | 0.73 | ALDH1A1 (0.36) | KDM4EMAPTALDH1A1NPC1CHRNB4 | |
| SCHEMBL31601053 | 0.73 | HSP90AA1 (0.44) | KDM4EMAPTALDH1A1HSP90AA1HSP90AB1 | |
| SCHEMBL23329532 | 0.72 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009032703-A1 | 2- (HET) ARYLAMINO-6-AMINOPYRIDINE DERIVATIVES AND FUSED FORMS THEREOF AS ANAPLASTIC LYMPHOMA KINASE INHIBITORS | IRM LLC (BM) | 2009-03-12 | — | — | WO | disclosed |