Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049256 | 1.00 | PIK3CD (0.41) | PIK3CDPIK3CAPIK3CBPIK3CGADORA2A | |
| SCHEMBL4049475 | 0.94 | ADORA2A (0.42) | PIK3CDPIK3CAPIK3CBPIK3CGADORA2A | |
| SCHEMBL1761083 | 0.88 | HDAC3 (0.46) | PIK3CDPIK3CAADORA2AADORA1 | |
| SCHEMBL12592888 | 0.88 | HDAC3 (0.46) | PIK3CDPIK3CAADORA2AADORA1 | |
| SCHEMBL1760898 | 0.88 | HDAC3 (0.46) | PIK3CDPIK3CAADORA2AADORA1 | |
| SCHEMBL1760877 | 0.85 | ADORA2A (0.42) | PIK3CDPIK3CAADORA2AADORA1 | |
| SCHEMBL1760963 | 0.85 | ADORA2A (0.42) | PIK3CDPIK3CAADORA2AADORA1 | |
| SCHEMBL12592880 | 0.85 | ADORA2A (0.42) | PIK3CDPIK3CAADORA2AADORA1 | |
| SCHEMBL1760991 | 0.83 | ADORA2A (0.46) | PIK3CDPIK3CAADORA2AADORA1 | |
| SCHEMBL4052091 | 0.83 | ADORA2A (0.43) | PIK3CDPIK3CAPIK3CBPIK3CGADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-A1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007134958-A1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-11-29 | — | — | WO | disclosed |