Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 2/20 | 1.00 |
| ▸ | CES1 | P23141 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | TERT | O14746 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | APAF1 | O14727 | 2/20 | 0.52 |
| ▸ | TDP2 | O95551 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.52 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31141849 | 0.95 | PTPRC (0.91) | PTPRCCES1KMT2AMEN1NPC1 | |
| SCHEMBL9673985 | 0.95 | PTPRC (0.91) | PTPRCCES1KMT2AMEN1NPC1 | |
| Thiophenonaphthoquinone SCHEMBL29285 | 0.86 | PTPRC (0.76) | PTPRCCES1KMT2AMEN1NPC1 | |
| SCHEMBL727865 | 0.83 | CES1 (0.70) | PTPRCCES1KMT2AMEN1NPC1 | |
| SCHEMBL7318972 | 0.82 | CES1 (0.70) | PTPRCCES1KMT2AMEN1NPC1 | |
| SCHEMBL201792 | 0.80 | PTPRC (0.67) | PTPRCCES1KMT2AMEN1NPC1 | |
| SCHEMBL9674046 | 0.78 | CES1 (0.71) | PTPRCCES1DNMT1PABPC1 | |
| SCHEMBL2111492 | 0.78 | CES1 (0.70) | PTPRCCES1KMT2AMEN1DNMT1 | |
| SCHEMBL206335 | 0.78 | CES1 (0.79) | PTPRCCES1DNMT1PABPC1 | |
| SCHEMBL6995084 | 0.75 | CES1 (0.75) | PTPRCCES1KMT2AMEN1DNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242086-B1 | CD45 INHIBITORS | ASTRAZENECA AB (SE) | 2005-10-05 | — | — | EP | claimed |
| US-20030130298-A1 | Cd45 inhibitors | ASTRAZENECA AB (SE) | 2003-07-10 | — | — | US | claimed |
| EP-1242086-A2 | CD45 INHIBITORS | AstraZeneca AB (SE) | 2002-09-25 | — | — | EP | claimed |
| WO-2001045680-A2 | CD45 INHIBITORS | ASTRAZENECA AB (SE) | 2001-06-28 | — | — | WO | claimed |
| US-20090209571-A1 | Phenanthrene derivatives as MPGES-1 inhibitors | CELLUMEN INC. | 2009-08-20 | — | — | US | disclosed |
| EP-2024371-A1 | PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007134434-A1 | PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-11-29 | — | — | WO | disclosed |
| EP-1242086-B1 | CD45 INHIBITORS | ASTRAZENECA AB (SE) | 2005-10-05 | — | — | EP | disclosed |
| US-20030130298-A1 | Cd45 inhibitors | ASTRAZENECA AB (SE) | 2003-07-10 | — | — | US | disclosed |
| EP-1242086-A2 | CD45 INHIBITORS | AstraZeneca AB (SE) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001045680-A2 | CD45 INHIBITORS | ASTRAZENECA AB (SE) | 2001-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209571-A1 | Phenanthrene derivatives as MPGES-1 inhibitors | PTGES, PTGS1, PTGES2 | PTPRC 2968/4885CES1 213/4885KMT2A 2400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.