Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 11/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.37 |
| ▸ | FAP | Q12884 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | ANPEP | P15144 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049392 | 0.97 | HSD11B1 (0.34) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL4045968 | 0.86 | CTSK (0.33) | HSD11B1CTSK | |
| SCHEMBL4047889 | 0.85 | CTSK (0.33) | HSD11B1CTSK | |
| SCHEMBL4043974 | 0.82 | CTSK (0.33) | CTSK | |
| SCHEMBL4046572 | 0.82 | CTSK (0.34) | CTSK | |
| SCHEMBL4045017 | 0.82 | CTSK (0.33) | CTSK | |
| SCHEMBL4040194 | 0.82 | HSD11B1 (0.34) | HSD11B1CTSKPARP1 | |
| SCHEMBL4053300 | 0.81 | CTSK (0.33) | CTSK | |
| SCHEMBL4045302 | 0.81 | HSD11B1 (0.37) | HSD11B1CTSK | |
| SCHEMBL4052224 | 0.80 | CTSK (0.33) | CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |