Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | MTOR | P42345 | 15/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049748 | 0.86 | MAPT (0.45) | HRH3MTOR | |
| SCHEMBL4050241 | 0.81 | HTR6 (0.47) | HRH3MTORPIK3CAHTR2AHTR6 | |
| SCHEMBL4057700 | 0.79 | HRH3 (0.58) | HRH3PIK3CAPIK3CGHTR6 | |
| SCHEMBL4056388 | 0.78 | MTOR (0.60) | HRH3MTORPIK3CAHTR6 | |
| SCHEMBL4051355 | 0.72 | PIK3CA (0.46) | MTORPIK3CAPIK3CG | |
| SCHEMBL4051692 | 0.71 | HRH3 (0.43) | HRH3MTORPIK3CA | |
| SCHEMBL4057900 | 0.71 | SMN1; SMN2 (0.45) | HRH3MTOR | |
| SCHEMBL4057172 | 0.69 | MTOR (0.79) | MTORPIK3CAPIK3CG | |
| SCHEMBL3985904 | 0.69 | PIK3CA (0.74) | MTORPIK3CAPIK3CG | |
| SCHEMBL18025696 | 0.69 | PIK3CA (0.45) | HRH3MTORPIK3CAACHEPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111547-A1 | 7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH (US) | 2009-09-11 | — | — | WO | disclosed |