Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 14/20 | 0.49 |
| ▸ | PADI1 | Q9ULC6 | 1/20 | 0.39 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4044626 | 0.92 | CTSK (0.59) | CTSKPADI1PADI4CTSSCDK4 | |
| SCHEMBL4039596 | 0.86 | CTSK (0.62) | CTSKCTSSLMNAMAPT | |
| SCHEMBL4040318 | 0.84 | CTSK (0.60) | CTSKCTSSLMNAMAPT | |
| SCHEMBL4042027 | 0.84 | CTSK (0.64) | CTSKCTSSAURKA | |
| SCHEMBL4045203 | 0.83 | CTSK (0.54) | CTSKCTSSCDK4CCNA2CCND1 | |
| SCHEMBL6213222 | 0.81 | HPGDS (0.40) | CTSKAURKALMNAMAPT | |
| SCHEMBL4037734 | 0.80 | CTSK (0.55) | CTSKCTSSCDK4CCNA2CCND1 | |
| SCHEMBL4044020 | 0.80 | CTSK (0.75) | CTSKCTSSCDK4CCNA2CCND1 | |
| SCHEMBL4368912 | 0.80 | CTSK (0.75) | CTSKCTSSCDK4CCNA2CCND1 | |
| SCHEMBL4368915 | 0.80 | CTSK (0.75) | CTSKCTSSCDK4CCNA2CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |