Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 9/20 | 0.73 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.73 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.73 |
| ▸ | HTT | P42858 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4056982 | 0.91 | ADORA2B (0.65) | ADORA2BADORA1ADORA3HTTLMNA | |
| SCHEMBL4229255 | 0.89 | ADORA2B (0.72) | ADORA2BADORA1ADORA3KMT2ATSHR | |
| SCHEMBL4059617 | 0.86 | ADORA2B (0.75) | ADORA2BADORA1ADORA3HTTLMNA | |
| SCHEMBL4060758 | 0.86 | ADORA2B (0.65) | ADORA2BADORA1ADORA3HTTLMNA | |
| SCHEMBL4054108 | 0.85 | ADORA2B (0.69) | ADORA2BADORA1ADORA3LMNAALDH1A1 | |
| SCHEMBL4053837 | 0.85 | ADORA2B (0.73) | ADORA2BADORA1ADORA3HTTLMNA | |
| SCHEMBL4055136 | 0.85 | ADORA2B (1.00) | ADORA2BADORA1ADORA3SMN1; SMN2ADORA2A | |
| SCHEMBL4055594 | 0.82 | ADORA2B (0.64) | ADORA2BADORA1ADORA3HTTLMNA | |
| SCHEMBL4056734 | 0.80 | ADORA2B (0.66) | ADORA2BADORA1ADORA3MEN1KMT2A | |
| SCHEMBL4056662 | 0.79 | ADORA2B (0.84) | ADORA2BADORA1ADORA3ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504398-B2 | potent and selective antagonists of adenosine receptors; Parkinson's disease, asthma, allergies, inflammation, atherosclerosis, hypertension, gastrointestinal disorders, cell proliferation and autoimmune diseases; sulfonamidation | LABORATORIOS ALMIRALL S.A. (ES) | 2009-03-17 | — | — | US | disclosed |
| EP-1492793-B1 | NEW-4-(PYRROLOPYRIMIDIN-6-YL)BENZENESULPHONAMIDE DERIVATIVES | ALMIRALL LAB (ES) | 2008-01-16 | — | — | EP | disclosed |
| US-20050261248-A1 | New-4-pyrrolopyrimidin-6-YL)benzenesulphonamide derivatives | LABORATORIOS ALMIRALL, S.A. (ES) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261248-A1 | New-4-pyrrolopyrimidin-6-YL)benzenesulphonamide derivatives | ADORA2B, ADORA2A, ADORA3 | ADORA2B 1/4885ADORA1 4/4885ADORA3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.