Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 5/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.43 |
| ▸ | CDK2 | P24941 | 4/20 | 0.43 |
| ▸ | CDK9 | P50750 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 5/20 | 0.43 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | HTR7 | P34969 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4063061 | 0.80 | CCNT1 (0.58) | AXLDRD4DRD2DRD3GPR84 | |
| SCHEMBL20111997 | 0.79 | HTR2A (0.51) | AXLDRD4DRD2DRD3GPR84 | |
| SCHEMBL9376538 | 0.77 | PSMD14 (0.41) | DRD4DRD2DRD3HTR2AHTR1A | |
| SCHEMBL9377656 | 0.75 | HTR6 (0.39) | GPR84HTR2ACYP3A4HTR6MAPK1 | |
| SCHEMBL9696184 | 0.75 | HTR2A (0.43) | GPR84CDK2HTR2ACYP2D6ALDH1A1 | |
| SCHEMBL5240727 | 0.75 | BCHE (0.42) | DRD4DRD2DRD3HTR2AHTR1A | |
| SCHEMBL21714505 | 0.73 | DRD4 (0.46) | AXLDRD4DRD2DRD3GPR84 | |
| SCHEMBL16720229 | 0.71 | AXL (0.53) | AXLDRD4DRD2DRD3GPR84 | |
| SCHEMBL3060875 | 0.70 | KMT2A (0.47) | AXLDRD4DRD2DRD3GPR84 | |
| SCHEMBL31317715 | 0.69 | CCNT1 (0.47) | DRD4DRD2DRD3CCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113461683-B | 7-azaindole heterocyclic compound and preparation method and application thereof | 青岛科技大学 | 2022-11-22 | — | — | CN | claimed |
| CN-113461683-A | 7-azaindole heterocyclic compound and preparation method and application thereof | 青岛科技大学 | 2021-10-01 | — | — | CN | claimed |
| CN-113461683-B | 7-azaindole heterocyclic compound and preparation method and application thereof | 青岛科技大学 | 2022-11-22 | — | — | CN | disclosed |
| CN-113461683-A | 7-azaindole heterocyclic compound and preparation method and application thereof | 青岛科技大学 | 2021-10-01 | — | — | CN | disclosed |
| CN-102170883-A | Compounds useful as inhibitors of protein kinases | ABBOTT LAB | 2011-08-31 | — | — | CN | disclosed |
| US-7622480-B2 | Selective H1 histamine receptor antagonists; bronchial asthma, allergic rhinitis, conjunctivitis, dermatitis, urticaria and other allergic diseases; e.g. 3-(4-[1-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]piperidin-1-ylmethyl)benzoic acid | LABORATORIOS ALMIRALL S.A. (ES) | 2009-11-24 | — | — | US | disclosed |
| US-20050176751-A1 | Azaindolylpiperidine derivatives as antihistaminic and antiallergic agents | LABORATORIOS ALMIRALL, S.A. (ES) | 2005-08-11 | — | — | US | disclosed |
| EP-0379314-B1 | 3-(1,2,5,6-Tetrahydropyridyl)-pyrrolopyridines | PFIZER (US) | 1994-03-23 | — | — | EP | disclosed |
| US-5169947-A | 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines | PFIZER INC. (US) | 1992-12-08 | — | — | US | disclosed |
| US-5051412-A | Pharmaceutically active 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines | PFIZER INC. (US) | 1991-09-24 | — | — | US | disclosed |
| WO-1990007926-A1 | 3-(1,2,5,6-TETRAHYDROPYRIDYL)-PYRROLOPYRIDINES | PFIZER INC. (US) | 1990-07-26 | — | — | WO | disclosed |
| EP-0379314-A1 | 3-(1,2,5,6-Tetrahydropyridyl)-pyrrolopyridines | PFIZER INC. (US) | 1990-07-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176751-A1 | Azaindolylpiperidine derivatives as antihistaminic and antiallergic agents | HRH2, HRH1, HRH4 | AXL 4468/4885DRD4 218/4885DRD2 58/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.